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KMID : 0358819840110020139
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1984 Volume.11 No. 2 p.139 ~ p.145
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EFFECT OF GLUCAN ON THE REPAIR PROCESS OF SKIN WOUND IN MICE
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Cho Bek-Hyun
Huh Woo-Hoe
Choi Suk-Hyun
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Abstract
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In an attempt to investigate the effect of glucan, i.e., RES stimulating agent, on the repair process of skin wound, we made simple skin wound in mice and then glucan was given intraperitoneally at dose of 10mg until taking specimen. The specimen were taken from wound area at various intervals and histological and enzym histochemical stains were done for the light microscopic examination.
The results obtained were as follows.
1. The glucan-treated wound showed more proliferation of macrophages and granulation tissue with decreased acute inflammatory exudates in the early than did control wound.
2. The glucan-treated wound showed more increase of acid and alkaline phosphatase and α-naphthyl acetate esterase activities than did control wound, but no changes in ATPase activities.
From these results, it may be concluded that glucan promotes repair process of skin wound.
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KEYWORD
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